The Overlooked Cannabinoid: CBDa
CBD is surely well known and widely accessible. But do you know it’s parent cannabinoid, CBDA? CBDA is the raw and unheated precursor to CBD, Cannibidiol. Over time, CBDA becomes CBD and even faster through heat (known as decarboxylation). This acidic version of CBD is more potent and has more powerful anti-inflammatory effects on our endocannabinoid system.1
CBDA is our favorite newly researched cannabinoid! Give us the chance to convince you the same, after reading this it is our hope that you will share our love for this incredible acidic compound. Prior to the last decade, CBDA was known as basically just the precursor to the much more popular and studied cannabinoid, CBD.
In short, scientists have discovered that CBD works to affect mood, stress and tension levels, arousal, nausea and discomfort. In combination, recent research has demonstrated that CBD and CBDA work effectively and offer a more well rounded experience, although both compounds are non-intoxicating.1
The actual chemical’s molecular structure is what first grabbed researchers’ attention. CBDA’s structure is very similar to other NSAIDs researchers had studied, which therefore piqued their interest in exploring the potential anti-inflammatory effects of CBDA. In which they found to be promising, as CBDA modulated the same COX-2 inhibitor behavior that allows NSAIDs to reduce inflammation.2 In 2013, a study performed in Canada discovered that CBDA was one thousand times more effective than CBD in binding to a specific serotonin receptor linked to anti-nausea and anti-anxiety effects when administered alongside low-doses of the traditional anti-nausea drug for chemotherapy patients, ondansetron (OND).3
Whether you are battling cancer or combatting stress from the current climate of chaos, we believe adding CBDA can benefit you. Many people report benefits from using both CBD and CBDA in low doses, multiple times a day. The goal is to start low and go slow to learn your own appropriate dose and protocol. For example, beginning by using 5-30mg once in the morning and once in the afternoon may offer more efficacious results than a macro dose, once a day. You don’t know until you try! Your body knows best and knows how to guide you. This is also an exercise in learning to listen to your body! We always say, start low and go slow and allow yourself the time and space to properly assess your response to best hone your dosage and frequency. Remember, as always, we are here to help!
1. Sulak, Dustin MD. CBD CBDa EBook.
2. Beadle, Alexander. CBDA Vs CBD: What Are the Differences?
3. Rock and Parker. Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats.